ALLOFLO™ UVEO Clinical Evidence
The Crest Study
One of the largest prospective cohorts in interventional glaucoma.
>450
eyes enrolled
16
locations
2+
years
4 PEER-REVIEWED PUBLICATIONS
117 eyes at 12 months 2
SAFETY &
EFFICACY
31 eyes at 24 months 4
SAFETY &
EFFICACY
243 eyes at 24 months 4
POST-OP SAFETY ANALYSIS
51 medically uncontrolled eyes at 12 months 2
SAFETY &
EFFICACY
Traditional
CycloDIALYSIS
The ability for cyclodialysis to significantly reduce IOP has beenunderstood for over 100 years.
Meta-analysis of 40 evidence-based studies: 1
More than 4,000 eyes
Data collected over a 100-year period
Up to 10 years of follow-up
Demonstrated average success rate comparable to MIGS
*Across all studies, the average qualified success rate was 72.3% (range: 33-97%) over follow-up periods of 6 to 132 months.
EFFICACY OF BIO-REINFORCED CYCLODIALYSIS
Multiple published studies evaluated safety and efficacy with statistically significant outcomes.
Studies included a diverse population, ranging in disease severity from mild to severe.
Studies included a diverse population, ranging in disease severity from mild to severe.
≤ 15.2 mmHg
MEAN POST-OPERATIVE IOP 2-5
12-24 month
≤ 0.8
MEAN POST-OPERATIVE NUMBER OF OHT MEDICATIONS 2-5
12-24 month
*Across all studies, the average qualified success rate was 72.3% (range: 33-97%) over follow-up periods of 6 to 132 months.
SAFETY PROFILE OF BIO-REINFORCED CYCLODIALYSIS
243 eyes
Timeframe
Percent of eyes
Clinical Hypotony3
≥ 30 days
< 0.5%
Elevated IOP**3
At/after 1 month post-op
< 5%
** Procedure related, >30 mmHg or +10 mmHg from baseline
31 eyes
Timeframe
Mean ECL
Endothelial Cell Loss4
24 months
< 10%†
† Consistent with expected loss seen after cataract surgery procedures. No eyes had significant (>30%) endothelial cell loss.
243 eyes
Timeframe
Percent of eyes
Clinical Hypotony3
≥ 30 days
< 0.5%
Elavated IOP**3
At/after 1 month post-op
< 0.5%
31 eyes
Timeframe
Main ECL
Endothelial Cell Loss4
24 months
< 10%†
Real-world Application
Bio-intervention with AlloFloTM Uveo
3,000+
CASES 6
100+
U.S. SURGEONS 6
Contributors
PEER-REVIEWED PUBLICATIONS
Lautaro Vera, MD
Robert Weinreb, MD
Ticiana De Francesco, MD
Arsham Sheybani, MD
Nate Radcliffe, MD
Michael Patterson, DO
Leon Herndon, MD
Kevin Barber, MD
Gautam Kamthan, MD
Jorge Lince, MD
Douglas Rhee, MD
Ernesto Calvo, MD
Arkadiy Yadgarov, MD
Ehsan Sadri, MD
Craig Chaya, MD
Brian Flowers, MD
THE CREST STUDY
Lautaro Vera, MD
Won Kim, MD
Toby Tyson, MD
Stephen Smith, MD
Reena Garg, MD
James Lewis, MD
Gabriel Ferreira, MD
Eva Liang, MD
Ehsan Sadri, MD
Rajen Desai, MD
Deepan Selvadurai, MD
Craig Chaya, MD
Brian Flowers, MD
Arian Moses, MD
Surgical Videos
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